Facile synthesis of some novel 2-substituted-4,6- diarylpyrimidines using 4'-hydroxy-3',5'-dinitrochalcones and S- benzylthiouronium chloride
نویسندگان
چکیده
Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1pyrrolidinyl /1-piperidinyl)pyrimidines 4, 5 and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DMF, which on treatment with heterocyclic secondary amines gave products 4, 5 and 6 in an alternate two-step process.
منابع مشابه
ZnO Catalyzed Efficient Synthesis of Some New 2-Substituted-4,6-diarylpyrimidines
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